Zvakanakira Capsule

Muna 1500 BC, yekutangacapsuleakaberekerwa muIjipiti.

Muna 1730, vemishonga muVienna vakatanga kugadziracapsuleskubva starch.

Muna 1834,capsuletekinoroji yekugadzira yaive patented muParis.

Muna 1846, zvikamu zviviri zvakaomacapsuletekinoroji yekugadzira yakawanikwa muFrance Patents.

Muna 1848, maviri-chidimbucapsulesakabuda.Kubva ipapo,Empty hard capsule shellsakapinda munyika yezvokurapa ndokuva midziyo yokuisa mishonga.

Muna 1874, kugadzirwa kwemaindasitiri kwakaomacapsules(Hubel) yakatangwa muDetroit, uye mhando dzakasiyana dzakaunzwa panguva imwe chete.

Muna 1888, Parke-Davis akawana patent yekugadzirayakaoma capsulesmuDetroit (JB Russell)

Muna 1931, Parke-Davis '.capsulekukurumidza kugadzira kwakasvika 10,000capsulespaawa (A. Colton)

Seyakanakisa mishonga yekurongedza zvinhu,Empty hard capsule shellsanoshandiswa zvakanyanya mukugadzirira kwemishonga.Ivo vanonyanya kugoverwa muupfu, mvura, semi-yakasimba, mafuta ekuzora, mahwendefa uye mamwe magadzirirwo.Dzinogona kukurumidza, dzakavimbika uye dzakachengeteka kuora.Vane zvinotevera zvakanakira:

1) Yakanaka kupenya uye iri nyore kumedza.

2) Masking effect: Inogona kuvhara kusagadzikana kuvava uye kunhuwa kwemushonga, uye kudzivirira nekudzikamisa izvo zvisina kugadzikana zviri mukati.

3) Yakakwira bioavailability yemushonga:Capsuleshazvidi kunamatira uye kudzvinyirira panguva yekugadzirira semapiritsi nemapiritsi, saka vanopararira nekukurumidza uye vanotora zvakanaka mudumbu nemumatumbo.

4) Kudzivirirwa kurinani kwezvigadzirwa zvemishonga: Pasina tembiricha yakakwira uye yakanyanya kudzvanywa inounzwa nepiritsi rekudhinda, mamiriro echisikigo echirimwa mishonga yemishonga mucapsuleinogona kuchengetedzwa.

5) Inogona kugadzirwa mune inoenderera-kuburitswa gadziriro uye gadziriro dzekomboni:

Mushonga unogona kusunungurwa munguva uye nzvimbo (enteric-coated, pulsed uye mamwe maitiro ekubudisa zvinodhaka).Kana mushonga wacho ukatanga kugadzirwa kuita zvidimbu, uye ipapo gelatin mbishi zvinhu uye zvinhu zvine mitengo yakasiyana yekuburitsa zvinoshandiswa, mhedzisiro yenguva uye yekumisikidza kuburitswa inogona kuwanikwa.Naizvozvo,capsulesndiwo mafomu akakodzera emushonga ekuvandudza gadziriro-yekusunungurwa-yakagadziriswa uye gadziriro dzekomboni.

6) Kunyorerwa uye maitiro ekugadzirira ari nyore, akanakira maindasitiri uye otomatiki Kugadzira.