Zvakanakira Capsule

Muna 1500 BC, capsule yekutanga yakazvarwa muEgypt.

Muna 1730, vemishonga muVienna vakatanga kugadzira capsules kubva starch.

Muna 1834, tekinoroji yekugadzira capsule yaive patented muParis.

Muna 1846, tekinoroji yemhando mbiri-yakaoma capsule yekugadzira yakawanikwa muFrance Patents.

Muna 1848, makapu maviri-chidimbu akabuda. Kubva ipapo zvichienda mberi, Empty hard capsule shells akapinda munyika yezvokurapa ndokuva midziyo yekurongedza yemishonga.

Muna 1874, kugadzirwa kwemaindasitiri kweakaoma capsules (Hubel) kwakatangwa muDetroit, uye mhando dzakasiyana dzakaunzwa panguva imwe chete.

Muna 1888, Parke-Davis akawana patent yekugadzira macapsules akaoma muDetroit (JB Russell)

Muna 1931, Parke-Davis 'capsule yekugadzira speed yakasvika 10,000 capsules paawa (A. Colton)

Seyakanaka mishonga yekurongedza zvinhu, Empty hard capsule shells anoshandiswa zvakanyanya mukugadzirira mishonga. Ivo vanonyanya kugoverwa muupfu, mvura, semi-yakasimba, mafuta ekuzora, mahwendefa uye mamwe magadzirirwo. Dzinogona kukurumidza, dzakavimbika uye dzakachengeteka kuora. Vane zvinotevera zvakanakira:

1) Yakanaka kupenya uye iri nyore kumedza.

2) Masking effect: Inogona kuvhara kusagadzikana kuvava uye kunhuwa kwemushonga, uye kudzivirira nekudzikamisa izvo zvisina kugadzikana zviri mukati.

3) High bioavailability yemushonga: Capsules haidi kunamatira uye kumanikidzwa panguva yekugadzirira semapiritsi nemapiritsi, saka vanopararira nokukurumidza uye vanotora zvakanaka mudumbu uye mumatumbo.

4) Kudzivirirwa kuri nani kwezvigadzirwa zvemishonga: Pasina tembiricha yepamusoro uye yakanyanya kudzvanywa inounzwa nepiritsi yepiritsi, mamiriro echisikigo echirimwa mishonga yemishonga mu capsule inogona kuchengetedzwa.

5) Inogona kugadzirwa mune inoenderera-kuburitswa gadziriro uye gadziriro dzekomboni:

Mushonga unogona kusunungurwa munguva uye nzvimbo (enteric-coated, pulsed uye mamwe maitiro ekubudisa zvinodhaka). Kana mushonga wacho ukatanga kugadzirwa kuita zvidimbu, uye ipapo gelatin mbishi zvinhu uye zvinhu zvine mitengo yakasiyana yekuburitsa zvinoshandiswa, mhedzisiro yenguva uye yekumisikidza kuburitswa inogona kuwanikwa. Naizvozvo, macapsules akakodzera dosage mafomu ekuvandudza-kuburitswa-kuburitswa gadziriro uye gadziriro dzekomboni.

6) Kunyorerwa uye maitiro ekugadzirira ari nyore, akanakira maindasitiri uye otomatiki Kugadzira.